The Role of Peripheral CD4+PD-1+ and CD8+PD-1+ T Lymphocytes in Triple Negative Breast Cancer Patients

Programmed cell death protein-1 and programmed ligand-1 pathway activation play a vital role that can be modulated by tumor cells to blunt host immune surveillance. Periphery expression level on cluster of differentiation 4+ 8+ T lymphocytes 185 female patients first diagnosed with triple negative breast cancer in Tianjin Medical University Cancer Institute Hospital were analyzed multicolor flow cytometry prior any anti-tumor treatment. Patients who received chemotherapy alone for 2-8 cycles sequential samples assessed response evaluation criteria solid tumors 1.1. Peripherally, the rate protein-1+ general group significantly higher than control (p<0.0001). Post treatment was lower baseline better neoadjuvant (all p<0.05). In contrary, both showed no difference between pretreatment post poor p>0.05). Peripheral are associated clinical